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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Insulin
supplement:
Phosphatidic Acid
Research Papers that Mention the Interaction
“The mechanism of action by which insulin increases phosphatidic acid (PA) and diacylglycerol (DAG) levels was investigated in cultured hepatoma cells (HEPG2).”
Involvement of phospholipids in the mechanism of insulin action in HEPG2 cells.“Evidence was obtained that PA interacts synergistically with insulin so as to elicit a growth stimulatory effect.”
Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium“ Insulin treatment lowered the Lyso, SPM, PI, PS and PA while PC and PE increased.”
“ Insulin (0.1 μM) shielded an increase in PA synthesis by [32P] incorporation using [γ‐32P]ATP as substrate and endogenous diacylglycerol (DAG) as co‐substrate.”
“Additionally, we demonstrated that PA and DAG generation is regulated differentially by insulin during aging.”
“Our results show that insulin modulates PA and DAG availability through the regulation of PLD/PAP2 and DAGK pathways in adult rat CC synaptosomes.”
“Physiologic concentrations of insulin (718 pmol/l for 30 min) increased the phosphatidic acid content in membranes from control but not from diabetic rats by 34.2% (p<0.02).”
“Using this new method, insulin addition increased both PA (87%) and LPA (217%) mass in Xenopus laevis oocytes.”
“We studied the mechanism whereby insulin activates de novo phosphatidic acid synthesis in BC3H-1 myocytes.”
“ Insulin provoked increases in [3H]glycerol labeling of phosphatidic acid (PA), diacylglycerol (DAG), and other glycerolipids within 30 s of stimulation.”
“During 30 min incubations, insulin release correlated closely with the accumulation of [14C]arachidonate-labelled PA (r2 = 0.98; P less than 0.01) or [14C]myristate-labelled PA (r2 = 0.97; P less than 0.01).”
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