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Last Updated: 2 years ago

Possible Interaction: Insulin and Phosphatidic Acid



Research Papers that Mention the Interaction

The mechanism of action by which insulin increases phosphatidic acid (PA) and diacylglycerol (DAG) levels was investigated in cultured hepatoma cells (HEPG2).
Physiological research  •  2003  |  View Paper
Evidence was obtained that PA interacts synergistically with insulin so as to elicit a growth stimulatory effect.
In Vitro Cellular & Developmental Biology - Animal  •  2007  |  View Paper
Insulin treatment lowered the Lyso, SPM, PI, PS and PA while PC and PE increased.
Neuroscience Letters  •  2006  |  View Paper
Insulin (0.1 μM) shielded an increase in PA synthesis by [32P] incorporation using [γ‐32P]ATP as substrate and endogenous diacylglycerol (DAG) as co‐substrate.
Journal of neuroscience research  •  2006  |  View Paper
Additionally, we demonstrated that PA and DAG generation is regulated differentially by insulin during aging.
Our results show that insulin modulates PA and DAG availability through the regulation of PLD/PAP2 and DAGK pathways in adult rat CC synaptosomes.
Journal of neuroscience research  •  2005  |  View Paper
Physiologic concentrations of insulin (718 pmol/l for 30 min) increased the phosphatidic acid content in membranes from control but not from diabetic rats by 34.2% (p<0.02).
Diabetologia  •  2004  |  View Paper
Using this new method, insulin addition increased both PA (87%) and LPA (217%) mass in Xenopus laevis oocytes.
Journal of Lipid Research  •  2003  |  View Paper
We studied the mechanism whereby insulin activates de novo phosphatidic acid synthesis in BC3H-1 myocytes.
Biochemistry  •  1990  |  View Paper
Insulin provoked increases in [3H]glycerol labeling of phosphatidic acid (PA), diacylglycerol (DAG), and other glycerolipids within 30 s of stimulation.
Archives of biochemistry and biophysics  •  1990  |  View Paper
During 30 min incubations, insulin release correlated closely with the accumulation of [14C]arachidonate-labelled PA (r2 = 0.98; P less than 0.01) or [14C]myristate-labelled PA (r2 = 0.97; P less than 0.01).
The Biochemical journal  •  1990  |  View Paper
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