Possible Interaction: Insulin and Oxytocin

“In vivo administration of oxytocin to mice significantly reduced overall blood glucose levels and increased plasma insulin concentrations in response to a glucose challenge.”

“For example, a single intranasal dose of oxytocin can reduce caloric intake, increase fat oxidation and improve insulin sensitivity in men.”

“ Insulin decreases NPY (neuropeptide Y) and increases oxytocin mRNA levels in the amygdala.”

“ Oxytocin attenuated the peak excursion of plasma glucose and augmented the early increases in insulin and C-peptide concentrations in response to the glucose challenge, while slightly blunting insulin and C-peptide peaks.”

“Both oxytocin analogues enhanced insulin sensitivity, reduced HOMA-IR and increased bone mineral density.”

“ Insulin increased cytosolic calcium concentration ([Ca2+]i) in oxytocin neurons with larger (≧25 μm) and smaller (<25 μm) diameters isolated from PVN in C57BL/6 mice.”

“These findings prompted us to hypothesize that insulin serves to promote oxytocin release.”

“Moreover, in the skeletal muscle of lean rats oxytocin treatment downregulated insulin signal transduction by decreasing of insulin receptor substrate 1 protein level and stimulating of its serine phosphorylation.”

“However, insulin (Ins; 3 ng/ml) increased OT release, and increasing the glucose concentration in the presence of insulin (Ins+Glu) resulted in a sustained elevation in both OT and VP release that was not prevented by alloxan, a GK inhibitor.”

“ Oxytocin injections increased insulin and glucagon secretions, while ACTH level was not altered.”

“The ICAs of insulin and glucagon after oxytocin was injected were higher than those of the control.”

“ Oxytocin release was increased by glucose in the presence of insulin.”