Possible Interaction: Insulin and Oleic Acid

“The formation of an oleic variant of the metabolism of fatty acids under the action of insulin led to the improvement of the energy supply of cells and the high kinetic parameters of many species of herbivorous mammals, including Homo sapiens.”

“Biomass, S. mutans colonies and insoluble extracellular polysaccharide production were reduced from the biofilms treated with oleic and linoleic fatty acids (p < 0.05).”

“ Oleic acid (1 μM) significantly increased insulin (0.1 nM)-stimulated glucose uptake in 3T3-L1-GLUT4myc adipocytes, although oleic acid by itself had no effect on the glucose uptake.”

“ Oleic acid (1 μM) stimulated insulin (0.1 nM)-induced phosphorylation of the insulin receptor at Tyr1185 and increased insulin (0.1 nM)-induced phosphorylation of Akt at Thr308 and Ser473 in differentiated 3T3-L1-GLUT4myc adipocytes.”

“In contrast, leptin (10 ng/ml) and insulin (0.60 ng/ml)) stimulated the uptake of oleic acid (7.4+/-2.3 nmol/mg protein) in human adipose cells, SGBS cells by 1.28- and 2.48-fold (P<0.05), respectively.”

“In addition, in the presence of a sustained increase in oleic acid concentration, there is a decrease in the action of insulin to inhibit triacylglycerol secretion.”

“Additionally, the effect of insulin was inhibited by oleic acid , serum components, and NFY enforced expression.”

“Lipid accumulation and expression levels of AD-specific genes were enhanced by both OA and LA in the presence of insulin but not by OA or LA alone.”

“ Insulin and IGF-I significantly reduced the production of CO(2) from oleic acid with respect to the control values.”

“ResultsOleic acid and peanut oil high in oleic acid were able to enhance insulin production in INS-1.”

“We also show that oleic acid treatment decreases the insulin sensitivity of heart muscle cells, and this sensitivity is completely restored by transfection with SNAP23.”