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Possible Interaction: Insulin and Niacin

drug:

Insulin

supplement:

Niacin

Research Papers that Mention the Interaction

The short-term administration of a nicotinic acid analogue (acipimox) increases insulin sensitivity and consequently glucose disposal, both in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in patients with cirrhosis.
Metabolism: clinical and experimental  •  1993  |  View Paper
Nicotinic acid also reduced insulin action in HuH7 and primary hepatocytes, independently of the activation of hepatic PKCε.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2014  |  View Paper
Activation of both nicotinic and muscarinic M(3)/M(4) receptors resulted in reduction of insulin release when compared with stimulation of muscarinic receptor alone in Beta-TC6 cells.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  •  2010  |  View Paper
In addition, we have previously reported evidence that nicotinamide increases the insulin content of cells differentiated from embryonic stem (ES) cells, but the possibility of nicotinamide acting as a differentiating agent on its own has never been completely explored.
Experimental cell research  •  2008  |  View Paper
Five to 50 mM of NA dose-dependently reduced inhibition of accumulated islet insulin release induced by 150 pg/ml of IL-1 β.
Diabetes  •  1994  |  View Paper
We have previously observed possible nicotinic involvement in insulin release.
Diabetes research and clinical practice  •  1989  |  View Paper
Co-administered with niacin , high-fat meals significantly increased the postprandial concentrations of glucose, insulin , C-peptide, triglycerides, FFAs and postprandial indices of β-cell function.
Journal of the science of food and agriculture  •  2018  |  View Paper
In obese men, insulin sensitivity decreased after niacin treatment.
International Journal of Obesity  •  2018  |  View Paper
Prolonged high niacin or nicotinamide intake has been reported to reduce insulin sensitivity in individuals with normal or impaired glucose tolerance [7–9].
Diabetologia  •  2015  |  View Paper
Six … ER niacin led to a significant reduction in … adipocyte size associated with increased insulin sensitivity in isolated adipocytes and gene expression changes including increased adiponectin, C/EBPalpha, C/EBPdelta, PPARgamma and … carnitine palmitoyl transferase 2, hormone sensitive lipase, nicotinic acid receptor (GPR109B) and fatty-acid synthase mRNA expression.
Atherosclerosis  •  2009  |  View Paper
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