Possible Interaction: Insulin and Methionine

“RE → M and M → RE reduced the insulin iAUC by 35 and 48%, respectively, compared with NoRE (P < 0.01).”

“Homeostasis Model Assessment (HOMA)-estimated insulin sensitivity increased by 37.7% (95% CI: 22.8 to 54.5) in RSG + MET and 6.9% (95% CI: –6.2 to 21.9) in up-titrated MET recipients.”

“Furthermore, MR activated AMP-activated protein kinase and inhibited its downstream signalling and up-regulated insulin signalling-related molecules in gastrocnemius muscle.”

“Both GLP-1 and insulin at lower concentration of 10-9 M induced [Ca2+]i increases with smaller amplitude in lesser NG neuron population (4-7%).”

“Glucose (5 to 25 mM) stimulated, and insulin (10−10 to 10−7 M ) inhibited, luciferase expression driven by these promoters in primary cultured rat hepatocytes.”

“IAPP at 10−7 M reduced insulin release by 32% from 7.1 (95% Cl 5.8–8.6) to 4.8 (3.0–7.5) fmol · min−1 · islet−1 (P = 0.046, n = 7).”

“ Insulin … M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; … P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance.”

“By use of plasma enrichments, insulin decreased methionine rate of appearance (Ra; both methyl- and carbon Ra) by 25% (P < 0.003 vs. basal) and methionine disposal into proteins by 50% (P < 0.0005), whereas it increased homocysteine clearance by approximately 70% (P < 0.025).”

“The observation that M loaded on both factors suggests that a resistance to insulin action may provide the mechanism uniting the features of the insulin resistance syndrome.”

“Net negative balances of alanine, methionine , glycine, threonine and asparagine (typical substrates for system A amino acid transport) also were decreased by insulin , whereas serine (another substrate for system A transport) shifted from a zero balance to net uptake.”