Possible Interaction: Insulin and Melatonin

“The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin, which act through this pathway.”

“This is due to a functional inter-relationship between melatonin and insulin.”

“The results demonstrated that exogenous melatonin inhibited the expression of insulin mRNA in the MIN6 cells.”

“Accordingly, in insulin-secreting cells, melatonin reduced cAMP levels, and MTNR1B overexpression exaggerated the inhibition of insulin release exerted by melatonin.”

“The findings also imply that melatonin physiologically serves to inhibit nocturnal insulin release.”

“ Melatonin , a widespread substance with antioxidant and anti-inflammatory properties, has been found to act as an antidiabetic agent in animal models, regulating the release and action of insulin.”

“Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients.”

“The release of insulin was diminished under long‐term melatonin treatment.”

“Experimental evidence demonstrates that melatonin is necessary for the proper synthesis, secretion, and action of insulin.”

“The objective of this study was to test a hypothesis that insulin and IGF1 enhance IL‐17‐induced expression of inflammatory chemokines/cytokines through a glycogen synthase kinase 3β (GSK3B)‐dependent mechanism, which can be inhibited by melatonin.”

“ Melatonin administration has been shown to inhibit insulin release by acting through both MT1 and MT2 melatonin receptors present in pancreatic β-cells.”