Possible Interaction: Insulin and Mannose

“In contrast to the generation of lactate, that of glycogen from mannose was enhanced in the presence of insulin.”

“Glucose, mannose , fructose, glyceraldehyde and dihydroxyacetone all at 8 mM, significantly enhanced the release of insulin elicited by basal concentrations of these carbohydrates (2 mM).”

“3) The observation that mannose , inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect.”

“We also found that the effect of insulin on lipogenesis was blocked by mannose , glucosamine and inositol monophosphate, whereas the insulin effects on 3-O-methylglucose, cyclic AMP and lipolysis were unaffected.”

“ Mannose (15 mM) stimulated the release of insulin and somatostatin.”

“A lower rate of mannose oxidation appeared to account for its weaker stimulating efficacy for Ca uptake and insulin release.”

“The formation of the insoluble complex is pH‐dependent and can be inhibited by α‐methyl‐D‐mannoside, D‐mannose and D‐glucose.”

“Bacillus subtilis protease, Type VIII (subtilopeptidase A, EC 2.4.4.16), like insulin , stimulated the uptake of mannose and the incorporation of the isotope from [1- 14 C]mannose into CO 2 , fatty acid, glyceride-glycerol, protein, and glycogen in isolated adipose cells. [”

“ Insulin , but not B. subtilis protease, lowered the apparent K m of the mannose oxidation by adipose cells, whereas insulin and the protease were without effect on the apparent K m of galactose oxidation.”