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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Insulin
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“As a result of the activation of the membrane ATPase enzyme system by insulin , concentrations of K+ and Mg++ increase at critical intracellular loci; these ions then serve as “second messengers.””
Insulin Action at the Molecular Level: Facts and Speculations“Ca(II) and Mg(II) ions play an important role in the secretion of insulin.”
“In conclusion, Mg increased insulin sensitivity even in healthy normomagnesemic subjects.”
“The effects of insulin on initial rates measured with Mn++, or the initial or final rates measured with Mg++ , were less evident.”
Kinetic studies of adenylyl cyclase of fat cell membranes“An increase of magnesium ions from 1.0 mMol/l to 2.5-7.5 mMol/l strikingly inhibits insulin and glucagon release by approximately 50%, which is compensated for insulin by increasing the Ca2+-content of the medium.”
“This indicates that adjuvant interaction with the calcium and magnesium ion located in the rectal membrane is involved in the enhanced absorption of insulin and inulin.”
“While the omission of magnesium ion from the incubation medium is reported not to affect the release of insulin stimulated by glucose, it nevertheless greatly depresses the biosynthesis of insulin.”
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