Possible Interaction: Insulin and Long Chain Fatty Acid

“The insulin in physiological way deprives mitochondrions a possibility to metabolize ketone bodies, short chain, medium chain and long chain fatty acids and 'forces" them to oxidize glucose which phylogenetically is not an optimal substrate.”

“Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance.”

“Given that insulin acutely stimulates LCFA uptake, there was dramatically similar trend of dose‐response curves for ET‐1‐suppressed LCFA uptake, and also similar corresponding IC50 values, between basal and insulin‐stimulated states, reflecting that ET‐1 predominantly suppresses basal LCFA uptake.”

“Inhibition by insulin of long chain fatty acid oxidation in mitochondria is mediated in part by elevating malonyl-CoA levels, which inhibit carnitine palmitoyl-transferase I. Whether insulin alters peroxisomal oxidation has not been studied.”

“Both stimulation of Glc-6-Pase mRNA by LCFAs and clofibrate were inhibited by insulin.”

“The effects of Bt2cAMP and LCFA were antagonized by insulin , also dose dependently.”

“ Insulin at physiological concentrations can suppress catecholamine activation of the membrane transport of long chain fatty acids in the adipocyte.”

“In the perfused rat liver insulin inhibits the oxidation of serum free fatty acids [1 ] and endogenous fatty acids [2], increases the secretion of very low density lipoprotein triacylglycerol [1-3] and also opposes the antilipogenic effect of long chain free fatty acids [3].”