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“ Linolenic acid (C18:3) produced greater permeability of insulin through epidermis than did other fatty acids during passive (44.45 × 10− 4 cm/h) and iontophoretic (78.03 × 10− 4 cm/h) transport.”
Pharmaceutical development and technology • 2005 | View Paper
“Effects of α-linolenic acid, omega-6, and total PUFA on diagnosis of diabetes were unclear (as the evidence was of very low quality), but little or no effect on measures of glucose metabolism was seen, except that increasing α-linolenic acid may increase fasting insulin (by about 7%).”
International journal of pharmaceutics • 2020 | View Paper
“Our results indicate that the in vivo colonic administration of alpha-LA promotes secretion of incretin GLP-1 by activating the ERK pathway in L-cells and thereby enhances the secretion of insulin.”
Biochemical and biophysical research communications • 2006 | View Paper
“Stimulation by insulin was blocked by dibutyryl-cAMP and by polyunsaturated fatty acids, such as alpha-linolenic acid , gamma-linolenic acid, or eicosapentaenoic acid; palmitic or oleic acids, however, had no inhibitory effect.”
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia • 1985 | View Paper
“We identify interactions between insulin and ALA , where two PUFA biosynthesis genes that were induced by insulin or ALA alone, were highly down-regulated when insulin and ALA were combined.”