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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Insulin
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“Among polyunsaturated fats, linoleic acid from the n-6 series improves insulin sensitivity.”
Dietary fats and prevention of type 2 diabetes.“In addition, insulin induces tyrosine phosphorylation of IR/IGF1R and migration in MDA‐MB‐231 cells pretreated with LA , whereas it augments the increase in migration in MCF‐7 cells pretreated with LA.”
“In summary, our findings demonstrate that treatment with LA induces a higher response to insulin in breast cancer cells.”
“Pretreatment of MDA‐MB‐231 cells with LA induces invasion, proliferation, and increase the MMP‐9 secretion induced by insulin.”
“We also showed that linoleic acid , a representative PUFA, attenuated the actions of insulin and Dex on fatty acid and lipid synthesis as well as FAS activity and expression.”
“Lipid accumulation and expression levels of AD-specific genes were enhanced by both OA and LA in the presence of insulin but not by OA or LA alone.”
Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin“In particular, diets enriched in essential fatty acids LA and/or ALA) markedly improve insulin sensitivity and composition of weight regained, independently of the n-6:n-3 fatty acid ratio.”
“ Linoleic acid also induced a significant decrease (~20%) in adiponectin secretion (P < 0.05), but only in the presence of insulin and at the highest concentration tested (200 μM).”
“In the same experiments, 5 mM linoleic acid stimulated insulin release to 11,260 +/- 867 pg (P less than 0.05).”
“The conversion of linoleic to alpha-linolenic acid decreased when the amount of insulin injected was 5 U/kg or more.”
“They also suggest that the enhancement of linoleic acid desaturation by insulin is probably mediated via a glycolysis-independent mechanism.”
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