Possible Interaction: Insulin and Levocarnitine

“The fasting BS-level was significantly lower after the treatment - 3.85 ± 0.43 vs. 4.76 ± 1.02 mmol/L; p <0.… increased (72.8 ± 43.2 vs. 35.2 ± 18.3 mcmol/L; p <0.05) Improving the oxidative processes in peripheral tissues, L-carnitine … insulin and ….”

“ l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance.”

“ L-carnitine has also been shown to improve insulin sensitivity and elevate pyruvate dehydrogenase (PDH) flux.”

“ L-carnitine decreased malondialdehyde, glucose, insulin , HbA1c and MuRF1 and increased ISI and antioxidants.”

“Contrary to our hypothesis, despite significant activation of PKB and 2DG uptake, insulin did not increase l-carnitine uptake at 100 nM. However, l-carnitine uptake was modestly increased at a dose of 150 nM insulin.”

“Concomitant administration of L-carnitine increased plasma insulin concentrations, decreasing plasma glucose and HbA1c levels.”

“ L-Carnitine supplementation significantly reduced FPG, insulin , HOMA-IR, and HbA1c levels.”

“ L-carnitine supplementation resulted in a significant reduction in ….57; 95 % CI: -6.88, -2.25), insulin (WMD: -1.21; 95 % CI: -1.85, -0.57), homeostatic model assessment for insulin resistance (HOMA-…: -0.90, -0.44) and HbA1C concentrations (WMD: -0.30; 95 % CI: -0.47, -0.13).”