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Last Updated: 3 months ago

Possible Interaction: Insulin and Leucine

drug:

Insulin

supplement:

Leucine

Research Papers that Mention the Interaction

…,insulin also decreased (….001) leucine nitrogen flux substantially more than leucine carbon flux, indicating increased leucine transamination (an important biochemical process for nitrogen transfer between amino acids … the organs), in a dose-dependent manner, with the magnitude of effect being greater on skeletal muscle than on the splanchnic bed.
Diabetes  •  1998  |  View Paper
With the OPD, insulin stimulation was faster and plasma concentrations of leucine and insulin were correlated (r = 0.77, P < 0.01).
The American journal of clinical nutrition  •  1998  |  View Paper
It is suggested that insulin , by lowering the arterial concentration of leucine and isoleucine, inhibited the myocardial uptake of these amino acids.
The Journal of thoracic and cardiovascular surgery  •  1992  |  View Paper
The clearest effects of insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered free fatty acids and acylcarnitines.
Scientific Reports  •  2017  |  View Paper
A positive significant correlation was observed between insulin levels and both leucine and isoleucine (r = 0.232; P < 0.05).
Pediatric pulmonology  •  2017  |  View Paper
Background: Insulin and age affect leucine (and protein) kinetics in vivo.
The Journal of nutrition  •  2017  |  View Paper
L-tryptophan and L-leucine also modified plasma insulin concentration.
Scientific reports  •  2016  |  View Paper
Importantly, insulin increased net Leu and Phe balance across the leg and the balance between muscle protein synthesis and breakdown, but these changes were 45-140% lower (P < 0.03) in Pred than in placebo.
Insulin in both trials similarly suppressed whole body flux of Leu and Phe.
American journal of physiology. Endocrinology and metabolism  •  2009  |  View Paper
Leucine , when ingested alone, increased the serum insulin area response modestly.
Metabolism: clinical and experimental  •  2008  |  View Paper
The use of relatively high doses of insulin and additional glucose had a more pronounced effect on lowering leucine (and α-ketoisocaproate) blood levels than dietary elimination of leucine alone.
European Journal of Pediatrics  •  2005  |  View Paper
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