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“It is suggested that insulin , by lowering the arterial concentration of leucine and isoleucine , inhibited the myocardial uptake of these amino acids.”
The Journal of thoracic and cardiovascular surgery • 1992 | View Paper
“Eleven metabolites allowed differentiation between both diabetes types and alanine, α-amino-adipic acid, isoleucin , and stearic acid showed an inverse association with insulin sensitivity in both T2D and T1D combined.”
The Journal of clinical endocrinology and metabolism • 2016 | View Paper
“ Insulin also significantly reduced the efflux of isoleucine , tyrosine, phenylalanine, glutamine, and total amino acid nitrogen from forearm muscle.”
“As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine, phenylalanine, leucine, threonine and isoleucine.”
Hoppe-Seyler's Zeitschrift fur physiologische Chemie • 1980 | View Paper
“Chronic supplementation of isoleucine in mice on a high-fat/high-sucrose diet significantly reduced insulin release after an oral glucose challenge without any change in glucose tolerance curve, suggesting that isoleucine might have an insulin-sensitizing effect along with its acute hypoglycemic effect.”
American journal of veterinary research • 1983 | View Paper
“ Insulin significantly increased the ileal uptake of valine, isoleucine , leucine, tyrosine, threonine, and serine from arterial blood: uptake of these amino acids was approximately doubled 45 min after the end of the insulin infusion.”
The Journal of biological chemistry • 1980 | View Paper
“Protein synthesis in isolated diabetic liver cells as measured by the incorporation of radioactive isoleucine , valine and phenylalanine into protein decreases (5–6 fold) with time after insulin withdrawal.”