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Last Updated: 2 years ago

Possible Interaction: Insulin and Isoleucine

drug:

Insulin

supplement:

Isoleucine

Research Papers that Mention the Interaction

It is suggested that insulin , by lowering the arterial concentration of leucine and isoleucine , inhibited the myocardial uptake of these amino acids.
The Journal of thoracic and cardiovascular surgery  •  1992  |  View Paper
Eleven metabolites allowed differentiation between both diabetes types and alanine, α-amino-adipic acid, isoleucin , and stearic acid showed an inverse association with insulin sensitivity in both T2D and T1D combined.
The Journal of clinical endocrinology and metabolism  •  2016  |  View Paper
Insulin also significantly reduced the efflux of isoleucine , tyrosine, phenylalanine, glutamine, and total amino acid nitrogen from forearm muscle.
Surgery  •  1986  |  View Paper
As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine, phenylalanine, leucine, threonine and isoleucine.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie  •  1980  |  View Paper
Chronic supplementation of isoleucine in mice on a high-fat/high-sucrose diet significantly reduced insulin release after an oral glucose challenge without any change in glucose tolerance curve, suggesting that isoleucine might have an insulin-sensitizing effect along with its acute hypoglycemic effect.
Biological & pharmaceutical bulletin  •  2008  |  View Paper
Isoleucine and valine showed a negative correlation with insulin.
American journal of veterinary research  •  1983  |  View Paper
Insulin significantly increased the ileal uptake of valine, isoleucine , leucine, tyrosine, threonine, and serine from arterial blood: uptake of these amino acids was approximately doubled 45 min after the end of the insulin infusion.
Digestive diseases and sciences  •  1981  |  View Paper
This process is stimulated by glucose (but not by pyruvate) and by insulin , which also enhances the degradation of isoleucine and valine.
The Journal of biological chemistry  •  1980  |  View Paper
Protein synthesis in isolated diabetic liver cells as measured by the incorporation of radioactive isoleucine , valine and phenylalanine into protein decreases (5–6 fold) with time after insulin withdrawal.
Biochemical and biophysical research communications  •  1972  |  View Paper