Possible Interaction: Insulin and Iodine

“In 1926, Visscher & Muller observed the positive inotropic effects of insulin on the isolated beating turtle heart ( I).”

“As a Hispanic person, I have heard about the bad effects of insulin ever since I can remember.”

“However, I have several reservations about such large-scale use of insulin infusion pumps.”

“What I noticed was that the duration of effect of both intermediate and long-acting insulin preparations was considerably shorter than expected.”

“ Insulin levels increased during G and I (P < 0.01) with no difference (P > 0.05) between G and I during preinfusion (163 +/- 7.6 pmol/liter) or infusion (259 vs 264 +/- 16.”

“In those tissues that had previously been shown to exhibit a specific insulin uptake, the iodinated hormone uptake decreased proportionally with simultaneous injection of increasing amounts of unlabelled insulin.”

“In hearts from normal fed rats, perfusion with insulin (10m8 M) for 5, 10, and 15 min resulted in a 100% increase in the activity of the I (glucose 6-phosphate-independent) form of glycogen synthase.”

“Damage of iodinated hormones has been observed with insulin (YALOW & BERSON, 1960), ACTH (YALOW et al., 1964), growth hormone (GLICK et al., 1963), and glucagon (EISENTRAUT et al., 1968) and EISENTRAUT et al. (1968) have demonstrated that such damage can produce falsely high values in the plasma glucagon assay.”

“ Insulin rapidly produced an increase in per cent of total heart glycogen synthase in the I form in fed rats.”

“Addition of insulin to the basal medium enhanced significantly the incorporation of 131 I into protein-bound monoiodotyrosine, diiodotyrosine and thyrosine.”