Possible Interaction: Insulin and Guar Gum

“The 60 and 120 min areas under the curve for glucose and insulin were significantly reduced by the guar gum meal, as was the 240 min area under the curve for insulin.”

“Postprandial insulin and GIP levels were both significantly reduced by addition of guar gum to the carbohydrate meal.”

“The … the guar gum to the glucose drink … postprandial glucose and insulin levels over the following 2 h. This was associated with a reduction in the ratings for hunger and desire … and an increase in ratings for fullness and satiety, but energy intake from the test meal was unchanged.”

“In contrast, increased doses of guar gum led to a greater reduction in the postprandial rise in insulin.”

“Ingestion of guar gum decreases postprandial glycemia and insulinemia and improves sensitivity to insulin in diabetic patients and several animal models of diabetes.”

“ Guar gum induced lower postprandial insulin , alpha-amino-nitrogen and urea plasma concentrations.”

“Both concentrations of guar gum significantly reduced (P < 0.05) glucose absorption and insulin and GIP secretion rates over the 4 h postprandial period.”

“Production rates of insulin , gastric inhibitory polypeptide and insulin-like growth factor-1 (IGF-1) were lowest after guar gum ingestion.”

“The sampling was continued for 8 h. Guar gum strongly reduced the glucose absorption as well as the insulin , gastric inhibitory polypeptide (GIP) and insulin-like growth factor-1 (IGF-1) production.”

“The addition of guar gum , however, significantly reduced (P less than 0.05) the peak post-prandial plasma glucose concentration with diets LFM and LFST and also the peak plasma insulin concentration for all diets except for diet HFST in the morning.”

“The time taken to reach the peak post-prandial plasma glucose and insulin concentrations was not significantly affected by dietary fat but it was increased by the addition of guar gum , although the differences were not always significant.”