Possible Interaction: Insulin and Genistein

“The results showed that perinatal genistein intake could not only significantly reduce blood glucose levels, insulin and free fatty acids (FFA) in dams, but also improve glucose tolerance, insulin sensitivity and serum lipid profiles in adult female offspring.”

“Meanwhile, genistein effectively inhibited inflammation-enhanced mitogenic actions of insulin by down-regulation of endothelin-1 and vascular cell adhesion protein-1 overexpression.”

“ Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.”

“Compared to placebo, genistein significantly decreased fasting glucose and insulin , HOMA-IR, fibrinogen and homocysteine after 24 and 36 months of treatment.”

“RESULTS Compared with placebo, ge istein si gnificantly reduced fasting glucose and ins ulin as well as homeostasis model assessment for insulin resistance after both 12 and 24 months of treatment.”

“ Insulin is able to increase progresterone receptor (PR) levels while, in the presence of genistein , the above-reported effect was completely abolished.”

“Incubation of the purified enzyme with insulin simultaneously stimulated the tyrosine kinase and nitric oxide synthase activities of the preparations, that could be inhibited by genistein (an inhibitor of tyrosine kinase).”

“ Genistein (100 microM) time-dependently increased insulin mRNA levels in INS-1 cells.”

“The tyrosine kinase inhibitors genistein and tyrphostin 25 increased insulin release , but not their negative controls with isoflavonoid structure (daidzein and genistin).”

“By contrast, insulin action on Na+,K(+)-ATPase was impaired by the protein kinase inhibitors staurosporine and genistein.”

“The effects of insulin and IGF-1 were completely blocked by inhibitors of either tyrosine kinase ( genestein ) or nitric oxide synthase (L-NAME).”