supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Insulin
supplement:
Conjugated Linoleic Acid
Research Papers that Mention the Interaction
“ Insulin sensitivity was significantly decreased (p<or=0.05) following CLA supplementation, with a significant increase in glucose and insulin area under the curve during an oral glucose tolerance test (p<or=0.005).”
Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans.“CONCLUSIONS CL su pplementation had an adverse effect on ins ulin an d glucose metabolism.”
“Compared with placebo, c9,t11 CLA decreased insulin sensitivity by 15% (P < 0.05) and increased 8-iso-prostaglandin F(2alpha) and 15-keto-dihydro-prostaglandin F(2alpha) excretion by 50% (P < 0.01) and 15% (P < 0.05), respectively.”
“These studies also report that CLA supplementation increased the risk factors for diabetes and cardiovascular disease including increased blood glucose, insulin , insulin resistance, VLDL, C-reactive protein, lipid peroxidation, and decreased HDL.”
“However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA.”
“This review presents our current understanding of potential isomer-specific mechanisms by which CLA reduces human adiposity and insulin sensitivity.”
“ CLA decreased leptin release (25%; P < 0.001) when insulin was present in the media, partially inhibiting insulin stimulation of leptin release.”
Conjugated linoleic acid and betaine affect lipolysis in pig adipose tissue explants.“… CLA diet … regulated insulin sensitivity in AT as it upregulated the transcription of various genes involved in insulin signaling, inflammatory responses, and ceramide metabolism, including protein kinase …, nuclear factor κ B1, toll-like receptor 4, caveolin 1, serine palmitoyltransferase long chain base subunit 1, and N-acylsphingosine amidohydrolase 1.”
“ Insulin was increased 24% by CLA , but not by Ac + CLA, and nonesterified fatty acids were increased 55% by Ac + CLA, but not by CLA alone.”
“No treatment effect was observed on plasma glucose and β-hydroxybutyrate, but an interaction was observed of CLA and Ac on plasma insulin and nonesterified fatty acids.”
“The results … with CLA significantly reduced body weight gain and white fat pad weight in the … of plasma free fatty acids (FFA), triglycerides (TGs), cholesterin (TC), leptin, insulin and blood glucose concentration in the obese rats of CLA group … decreased compared to the rats in the high-fat group.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback