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Last Updated: 2 years ago

Possible Interaction: Insulin and Chromium Picolinate

Research Papers that Mention the Interaction

In 3T3-L1 adipocytes, chromium picolinate (0-10 micromol) per se did not produce any effect, however, when co-incubated with insulin it significantly increased the intracellular triglyceride synthesis (EC50 = 363.7nmol/1).
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements  •  2004  |  View Paper
CONCLUSION Ch omium picolinate si gnificantly decreased TG, ins ulin, H OMA-IR, fetuin-A, the number of inflammatory factors, and increased QUICKI without changing FBS, HbA1C, TC, LDL, HDL, IL-17 levels and liver steatosis intensity in patients with NAFLD.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements  •  2020  |  View Paper
CrPic also significantly increased levels of insulin , tryptophan, and serotonin (P < 0.001) in the serum and brain, and decreased cortisol levels in the serum (P < 0.01).
Biological Trace Element Research  •  2012  |  View Paper
The induction of the PM expression of GLUT4, but not CD36, or substrate uptake by insulin and CrPic appears to be additive in adipocytes.
Biological Trace Element Research  •  2010  |  View Paper
The phagocytosis of Escherichia coli by macrophages was enhanced significantly (p<0.05) in medium containing 10–100 µg/L CrCl3 or 20–100 µg/L CrPic in the presence of insulin.
Biological Trace Element Research  •  2007  |  View Paper
In vitro study findings show that chromium picolinate (CrPic) may improve insulin sensitivity by enhancing intracellular insulin receptor.
Metabolism: clinical and experimental  •  2007  |  View Paper
Human studies suggest that chromium picolinate (CrPic) decreases insulin levels and improves glucose disposal in obese and type 2 diabetic populations.
Thus, CrPic supplementation enhances insulin sensitivity and glucose disappearance, and improves lipids in male obese hyperinsulinemic JCR:LA-corpulent rats.
The Journal of nutrition  •  2002  |  View Paper
A comparable stimulation of the mRNA and protein levels was caused by CrPic in the absence of insulin (P < 0.05), while the CrPic + insulin treatment caused a greater percentage stimulation of the Ca2+-ATPase mRNA level than either separate treatment (P < 0.05).
The Journal of nutrition  •  1998  |  View Paper
Conclusion: Chromium picolinate decreased FBS and insulin levels and, thus, increased insulin sensitivity in clomiphene citrate-resistance PCOS women.
Iranian journal of reproductive medicine  •  2013  |  View Paper
We recently found that chromium picolinate (CrPic), a nutritional supplement thought to improve insulin sensitivity in individuals with impaired glucose tolerance, enhances insulin action by lowering plasma membrane (PM) cholesterol.
Biochemical and biophysical research communications  •  2008  |  View Paper