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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Insulin
supplement:
Chromic Cation
Research Papers that Mention the Interaction
“ Chromium (III) has been shown to act as a pharmacological agent improving insulin sensitivity in rodent models of obesity, insulin resistance, and diabetes.”
The effects of the glycation of transferrin on chromium binding and the transport and distribution of chromium in vivo.“These data suggest that the potential for genotoxic side-effects of Cr(III) complexes may outweigh their possible benefits as insulin enhancers, and that recommendations for their use as either nutritional supplements or antidiabetic drugs need to be reconsidered in light of these recent findings.”
“ Chromium(III) has been reported to be an essential trace element involved in the control of glucose metabolism by insulin.”
“ Chromium(III) supplementation influence body composition and mass, glucose and lipid metabolism and it enhance insulin action.”
The Effects of High Dietary Doses of Chromium(III) Complex with Propionic Acid on Nutritional and Selected Blood Indices in Healthy Female Rats“Supplemental CrProp administered at 10- and 50-fold doses of the basal dietary Cr level has a significant antidiabetic effect in insulin resistant rats.”
“The influence of Cr(III) on the structural stability and state of aggregation of insulin and their possible role in glucose metabolism is discussed.”
“It has been shown that Cr(III) stabilizes insulin against the chymotrypsin-promoted hydrolysis of the protein.”
Chymotrypsin-catalyzed hydrolysis of chromium (III) derivatives of insulin: evidence for stabilization of the protein through interactions with metal ions.
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