Possible Interaction: Insulin and Calcium Supplement

“In cultured rat tracheal smooth muscle cells, insulin significantly increased M2, not M3, mRNA expression and enhanced methacholine- and serotonin-induced increase in intracellular calcium.”

“Thus, insulin , acutely potentiated agonist-induced increase in intracellular calcium and airway smooth muscle contraction.”

“ Calcium is one of the most potent triggers of β-cell growth, insulin production and exocytosis.”

“Zinc and calcium ions play important roles in the biosynthesis and storage of insulin.”

“In FURA-2 experiments, insulin caused a slow monophasic rise in HTC cell calcium , which depended on the presence of extracellular calcium.”

“ Insulin also induced significant increases of 1.58- and 1.54-fold in basal calcium influx when studied by external calcium withdrawal and readmission, or by the manganese quench method, respectively.”

“ Insulin (100 nm) increased cell volume in the presence of extracellular Ca2+ (1 mm), while cell shrinkage was induced by insulin in the absence of extracellular Ca2+ (<1 nm).”

“Several workers have demonstrated that insulin attenuates the agonist-induced intracellular Ca2+ ( Ca2+i ) transient in VSM, although the identity of the sarcolemmal and/or sarcoplasmic reticular Ca2+ transport systems that are affected by insulin is controversial.”

“In conclusion, insulin stimulates calcium transients but blunts agonist-mediated calcium rises in vascular smooth muscle cells.”

“S-layer protein and purified homologous but not heterologous LPS in the presence of calcium produced insoluble complexes.”

“Therefore, a decrease in the intracellular calcium concentration, mediated by blockade of the inward transport of calcium, should provoke an inhibition of insulin release as the size of the calcium pool diminishes.”

“One of the discussed mechanisms includes a shifting of calcium within the different cellular pools under the influence of insulin [ 2-51.”