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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Insulin
supplement:
Beta-Hydroxy-Beta-Methylbutyrate Supplement
Research Papers that Mention the Interaction
“In the presence of insulin , the inhibitory effect of HMB (0.34 ± 0.03) was still more effective than that of Leu (0.60 ± 0.04) and KIC (0.57 ± 0.08, P < 0.05).”
“…,HMB appears to be more potent than Leu and KIC … protein degradation in the absence or presence of insulin , and this inhibitory effect may be dependent on PI3K/Akt signaling pathway regardless of insulin, … mTOR signaling was only involved in this effect of HMB in the absence of insulin.”
β-Hydroxy-β-methyl Butyrate Is More Potent Than Leucine in Inhibiting Starvation-Induced Protein Degradation in C2C12 Myotubes.“ HMB significantly increased insulin tolerance and decreased fasting insulin , HOMA-IR, HBA1C, hepatic glycogen content, serum TG, LDL-C, and VLDL-C. Additionally, HMB enhanced ACh-induced relaxation, ameliorated hepatic steatosis, and decreased mRNA expression of GLUT-2.”
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