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Last Updated: 2 years ago

Possible Interaction: Insulin and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

Conclusions—These findings suggest that the endogenous NOS inhibitor ADMA reduces insulin sensitivity, consistent with previous observations that NO plays a role in insulin sensitivity.
Arteriosclerosis, thrombosis, and vascular biology  •  2008  |  View Paper
From the covariance analyses, both glucose and insulin relate significantly to ADMA in T1D + ESRD (beta = +0.004, beta = -0.038, respectively) and in KP (beta = +0.032, beta = +0.032, respectively).
Free radical biology & medicine  •  2009  |  View Paper
However, the association between insulin and ADMA levels in these reports does not necessarily mean that insulin itself is the cause of ADMA elevation.
In their recent article, Eid et al [1] hypothesized that acute infusion of insulin would increase asymmetric dimethylarginine ( ADMA) levels in a group of young men with mildly elevated blood pressures.
Metabolism: clinical and experimental  •  2008  |  View Paper
We conclude that acute changes in glycaemia do not significantly affect plasma ADMA levels whereas infusion of insulin significantly reduces ADMA , suggesting an important role for insulin in the regulation of this cardiovascular risk factor.
Clinical science  •  2008  |  View Paper
Short-term administration of insulin was accompanied by a decrease in both ADMA and L-arginine levels, with no change in FBF, in our population of young men with borderline hypertension.
Metabolism: clinical and experimental  •  2007  |  View Paper
RESULTS The dose-dependent TNFalpha-induced AD A ac cumulation was significantly inhibited when co-stimulated with ins ulin or adiponectin in both cell lines (p<0.01 for all), accompanied by significant increases in DDAH activity in all conditions.
Atherosclerosis  •  2007  |  View Paper
Plasma concentrations of ADMA are also influenced by insulin sensitizers such as rosiglitazone, indicating a possible link of NOS activity to the metabolic syndrome (9).
Clinical chemistry  •  2005  |  View Paper
Our results demonstrated that ADMA inhibits insulin sensitivity in a concentration‐dependent manner by activating inflammation factors tumor necrosis factor (TNF)‐α, interleukin (IL)‐1, and IL‐6 in primary hepatocytes.
Journal of cellular biochemistry  •  2018  |  View Paper