Possible Interaction: Insulin and Asymmetric Dimethylarginine

“Conclusions—These findings suggest that the endogenous NOS inhibitor ADMA reduces insulin sensitivity, consistent with previous observations that NO plays a role in insulin sensitivity.”

“From the covariance analyses, both glucose and insulin relate significantly to ADMA in T1D + ESRD (beta = +0.004, beta = -0.038, respectively) and in KP (beta = +0.032, beta = +0.032, respectively).”

“However, the association between insulin and ADMA levels in these reports does not necessarily mean that insulin itself is the cause of ADMA elevation.”

“In their recent article, Eid et al [1] hypothesized that acute infusion of insulin would increase asymmetric dimethylarginine ( ADMA) levels in a group of young men with mildly elevated blood pressures.”

“We conclude that acute changes in glycaemia do not significantly affect plasma ADMA levels whereas infusion of insulin significantly reduces ADMA , suggesting an important role for insulin in the regulation of this cardiovascular risk factor.”

“Short-term administration of insulin was accompanied by a decrease in both ADMA and L-arginine levels, with no change in FBF, in our population of young men with borderline hypertension.”

“RESULTS The dose-dependent TNFalpha-induced AD A ac cumulation was significantly inhibited when co-stimulated with ins ulin or adiponectin in both cell lines (p<0.01 for all), accompanied by significant increases in DDAH activity in all conditions.”

“Plasma concentrations of ADMA are also influenced by insulin sensitizers such as rosiglitazone, indicating a possible link of NOS activity to the metabolic syndrome (9).”

“Our results demonstrated that ADMA inhibits insulin sensitivity in a concentration‐dependent manner by activating inflammation factors tumor necrosis factor (TNF)‐α, interleukin (IL)‐1, and IL‐6 in primary hepatocytes.”