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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Insulin
supplement:
Arachidonate
Research Papers that Mention the Interaction
“ Arachidonate (0.25 mM) was a significantly more effective inhibitor of the insulin action than linoleate was.”
Free fatty acid inhibition of the insulin induction of glucose-6-phosphate dehydrogenase in rat hepatocyte monolayers“The Higher dose of insulin 100 units per kg body weight produced a 20% inhibition of arachidonate incorporation into synaptosomal PI and a 13% decrease of incorporation into microsomal phosphatidylcholine.”
“These results indicate that insulin induced deposition of cholesteryl esters and triglycerides, especially those containing monounsaturated fatty acids, and abnormal arachidonate distribution in LDL and tissues.”
“ Arachidonate , under similar conditions, enhanced rather than suppressed the release of insulin.”
“These results suggest that the level of intracellular arachidonate may play a major role in modulating insulin-stimulated phosphoinositide turnover and thereby indirectly regulate certain aspects of insulin action which involve lipid metabolism.”
“On the other hand Trovati et al(4) found reduced platelet aggregation responses to ADP, PAF, epinephrine, collagen and arachidonate in the presence of 40 µU/ml insulin.”
Possible role for platelet insulin receptors in modulating platelet function in health and diabetes mellitus.
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