Possible Interaction: Insulin and Alpha-lipoic acid

“ Alpha-lipoic acid has been shown to improve insulin action after parenteral administration.”

“ Insulin was able to partially reverse the inhibitory action of α-LA on chemerin secretion.”

“Recently, it has been suggested that α lipoic acid (ALA) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle AMP-activated protein kinase (AMPK).”

“Using ALA with insulin in patients with diabetes can show a synergistic effect against SARS-CoV-2.”

“Alpha-lipoic acid ALA ) has been reported to have beneficial effects for improving insulin sensitivity.”

“Indeed, bimoclomol--a heat shock protein co-inducer being developed for treatment of diabetic neuropathy--and lipoic acid--suspected … a heat shock protein inducer--have each demonstrated favorable effects on the insulin sensitivity of obese rodents, and parenteral lipoic acid is reported … improve the insulin sensitivity of … 2 diabetics.”

“The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes.”

“ Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects.”

“It was established that single administration of emoxipine, reamberin, mexidol and alpha-lipoic acid in optimal doses, corresponding to the therapeutic range in humans, increased the sensitivity of animals to insulin according to the criterion of insulin coma development.”

“Additionally, LA inhibited insulin expression and secretion in HIT‐T15 cells induced by high glucose.”

“ α‐lipoic acid (LA) has been used to prevent and treat diabetes, and is thought to act by increasing insulin sensitivity in many tissues.”