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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Inosine, guanosine, 2'-deoxyadenosine, tubercidin, formycin B, and the pyrimidines uridine , thymidine, and cytidine (all 100 microM) inhibited transport of adenosine and inosine about 50-100%, while 3'-deoxyinosine showed weak inhibitory action.”
Sodium-dependent nucleoside transport in mouse lymphocytes, human monocytes, and hamster macrophages and peritoneal exudate cells.“Mismatched base-pairing between inosine and uridine appears to be responsible for the observed characteristics of the unwound RNA.”
“The uptake of both uridine and DAC was inhibited by uridine, cytidine, adenosine, or inosine , while that of DAC was also inhibited by thymidine.”
“Further, we demonstrated that the apparent Km and Vmax values for Na-independent uridine transport were 67.… inosine for Na-independent uridine transport was 45.1 +/- 12.1 micromol/L. These results suggest that inosine … uridine uptake via the nucleoside transport pathway, and … systemic circulation via the hepatic vein.”
“In addition, the … urinary excretion of uridine was increased by 1.17-fold (P <.05) and that of hypoxanthine, xanthine, and uric acid by 1.38-fold (P <.…), 1.4-fold (P <.05), and 1.4-fold (P <.05) between 2 and 3 hours after the administration of inosine.”
“We also conducted an in vitro study with Mahlavu cells and found that the addition of inosine (50 micromol/L) inhibited a decrease in the concentration of uridine in medium originally containing 50 micromol/L uridine.”
“The effects of 24 mM uridine on growth and differentiation of HL-60 cells were also prevented by 5 mM inosine , and partially prevented by either 2 mM hypoxanthine or 20 microM adenosine.”
“The levels of hypoxanthine and uridine in the colorectal cancer mucosa samples and the inosine in gastric cancer samples were also significantly higher than those in normal mucosa.”
“Purine nucleoside phosphorylase-deficient cultured human fibroblasts accumulate inosine from the medium at 60% of the rate in wild type cells when the … 10 micronM and 30% of the normal rate when inosine is present at 100 micronM. When 10 micronM inosine is present, uridine but not … of inosine.”
“The uptake of inosine was saturable at high concentrations and was specifically inhibited by the presence of adenosine or uridine in the incubation media.”
Uptake and metabolism of purine nucleosides and nucleotides in isolated frog skeletal muscle.“Hydrolysis of uridine is inhibited by borate ions and by adenosine, inosine , and guanosine, but not by cytidine or xanthosine.”
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