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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Inosine and Tiazofurin



Research Papers that Mention the Interaction

Tiazofurin is known to inhibit inosine 5'-phosphate dehydrogenase (IMPDH), the rate limiting enzyme of de novo guanine ribonucleotide synthesis.
Anticancer research  •  1996  |  View Paper
Tiazofurin , a potent inhibitor of inosine 5'-phosphate dehydrogenase, depletes guanine nucleotide pools and induces granulocytic maturation of HL-60 leukemia cells.
Leukemia research  •  1991  |  View Paper
In addition, tiazofurin phosphorylation was competitively inhibited by inosine and the apparent Ki value was similar to the apparent Km value for inosine phosphorylation.
Cancer research  •  1986  |  View Paper
The cytostatic agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide EICAR ) causes a rapid and marked inhibition of inosinate (IMP) dehydrogenase activity in intact tumor cells.
Advances in experimental medicine and biology  •  1998  |  View Paper