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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Inosine
drug:
Tiazofurin
Research Papers that Mention the Interaction
“ Tiazofurin is known to inhibit inosine 5'-phosphate dehydrogenase (IMPDH), the rate limiting enzyme of de novo guanine ribonucleotide synthesis.”
Biochemically targeted therapy of refractory leukemia and myeloid blast crisis of chronic granulocytic leukemia with Tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.“ Tiazofurin , a potent inhibitor of inosine 5'-phosphate dehydrogenase, depletes guanine nucleotide pools and induces granulocytic maturation of HL-60 leukemia cells.”
“In addition, tiazofurin phosphorylation was competitively inhibited by inosine and the apparent Ki value was similar to the apparent Km value for inosine phosphorylation.”
“The cytostatic agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide EICAR ) causes a rapid and marked inhibition of inosinate (IMP) dehydrogenase activity in intact tumor cells.”
Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.
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