Discover Supplement-Drug Interactions
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6 months ago
Possible Interaction: Inosine and Tiazofurin
Research Papers that Mention the Interaction
is known to inhibit
5'-phosphate dehydrogenase (IMPDH), the rate limiting enzyme of de novo guanine ribonucleotide synthesis.”
Biochemically targeted therapy of refractory leukemia and myeloid blast crisis of chronic granulocytic leukemia with Tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.
Anticancer research • 1996 |
, a potent inhibitor of
5'-phosphate dehydrogenase, depletes guanine nucleotide pools and induces granulocytic maturation of HL-60 leukemia cells.”
Expression of memory to the terminal differentiation inducing activity of tiazofurin in HL-60 leukemia cells.
Leukemia research • 1991 |
phosphorylation was competitively inhibited by
and the apparent Ki value was similar to the apparent Km value for inosine phosphorylation.”
Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase.
Cancer research • 1986 |
“The cytostatic agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide
) causes a rapid and marked inhibition of
(IMP) dehydrogenase activity in intact tumor cells.”
Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.
Advances in experimental medicine and biology • 1998 |
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