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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Inosine and Tetrodotoxin

supplement:

Inosine

drug:

Tetrodotoxin

Research Papers that Mention the Interaction

“ Tetrodotoxin (0.5 gmol/1) abolished and absence of Ca2+ markedly reduced the electrically evoked release of adenosine and inosine.”
Endogenous adenosine release from hippocampal slices excitatory amino acid agonists stimulate release, antagonists reduce the electrically-evoked release
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
“ Tetrodotoxin reduced the outflow of adenosine and inosine by 42 and 33%, respectively, whereas the removal of Ca2+ caused a further increase.”
Investigations into the Adenosine Outflow from Hippocampal Slices Evoked by Ischemia‐Like Conditions
Journal of neurochemistry  •  1993  |  View Paper
“The (14)C-labelled compounds of which output was most inhibited by tetrodotoxin were adenosine, inosine and hypoxanthine whereas output in a nucleotide fraction was little affected.”
Output of (14C)adenine nucleotides and their derivatives from cerebral tissues. Tetrodotoxin-resistant and calcium ion-requiring components.
The Biochemical journal  •  1973  |  View Paper