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Last Updated: 2 years ago

Possible Interaction: Inosine and Ribavirin

supplement:

Inosine

Research Papers that Mention the Interaction

The absorption of ribavirin in the rat intestine was significantly reduced by coadministration of 10 mg/ml (=37.3 mM) inosine.
European journal of pharmacology  •  2008  |  View Paper
Depletion of intracellular GTP through inosine monophosphate dehydrogenase inhibition by RBV led to down-regulation of C/EBPα.
The Biochemical journal  •  2019  |  View Paper
RBV inhibits inosine 5′-phosphate dehydrogenase (IMPDH), the enzyme required for synthesis of guanosine monophosphate (GMS) as well as DNA and RNA synthesis.
Oncotarget  •  2015  |  View Paper
Ribavirin … inosine monophosphate dehydrogenase, limiting eneration of guanosine triphosphate pools in the cell, hich are necessary for viral (and cellular) replication.4 The observation that more … RNA-dependent RNA polymerase of HCV, and, therefore in theory, it could be a DAA itself.6 However, this mechanism also seems unlikely.
Gastroenterology  •  2012  |  View Paper
Ribavirin and mycophenolic acid are both inhibitors of inosine 5'-monophosphate dehydrogenase and cause a depletion of intracellular dGTP levels.
Antiviral research  •  2000  |  View Paper
Molecular modelling studies reveal that only the anti or high anti-glycosyl conformations of ribavirin can mimic the inosine base.
Biochimica et biophysica acta  •  1980  |  View Paper