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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Inosine
drug:
Pentostatin
Research Papers that Mention the Interaction
“High concentrations of deoxycoformycin and EHNA inhibit all pathways of purine ribonucleotide synthesis, and inhibit the conversion of inosinate to adenine and guanine nucleotides.”
Specificity of adenosine deaminase inhibitors.“Apparent ADA activity (as estimated by isotopic flux to inosine and hypoxanthine) was profoundly inhibited by dCF (with at least 50% inhibition at 10(-8) M and 95% inhibition at 10(-5) M dCF).”
“ Pentostatin also resulted in a significant reduction in the accumulation of inosine and hypoxanthine, indicating inhibition of adenosine deaminase activity.”
Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size“ Inosine , hypoxanthine, and xanthine levels were depressed by deoxycoformycin.”
“ Inosine and hypoxanthine release were attenuated at the higher dose of deoxycoformycin , acid release into the cortical perfusates was enhanced at the higher dose level.”
“Adenosine deamination, and thus its conversion to nucleotides via inosine‐hypoxanthine‐inosine monophosphate, was inhibited by pretreatment of the cells or cell extracts with 2‐deoxycoformycin.”
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