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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Inosine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Total leukocyte counts, myeloperoxidase, nitric oxide production, and proteins were all significantly decreased by inosine.”
Inosine Exerts a Broad Range of Antiinflammatory Effects in a Murine Model of Acute Lung Injury“A downstream metabolite of adenosine, inosine , also potentiated the LPS-induced NO production in a dose-dependent manner while its enhancement effect was also inhibited by dipyridamole.”
“The inhalation of nitric oxide lowered the pulmonary-to-systemic pressure ratio (Pp/Ps) (p < 0.0001) in the iNO group, and this ratio after the inhalation was significantly lower than that in the control group (p = 0.015).”
Inhaled nitric oxide improves pulmonary hypertension and organ functions after adult heart valve surgeries“… NO … inosine 5′-monophosphate dehydrogenase in de novo purine nucleotide biosynthesis and quinol oxidases in the electron transport chain, leading to drastic depletion of nucleoside triphosphates, … modestly decreases nucleoside triphosphates in glycolytic cells, which obtain much of their ATP by substrate-level phosphorylation and overexpress inosine 5′-monophosphate dehydrogenase.”
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