Possible Interaction: Inosine and Mycophenolic Acid

“BACKGROUND Mycophenolic acid is reported to provide effective immunosuppression by inhibiting inosine monophosphate dehydrogenase.”

“ Mycophenolic acid is reported to provide effective immunosuppression by inhibiting inosine monophosphate dehydrogenase.”

“ Mycophenolic acid and mizoribine inhibit inosine monophosphate dehydrogenase, thereby depleting guanosine nucleotides.”

“Here, we successfully induced the in vitro formation of Toxoplasma cysts-like structures from tachyzoites of the type I RH strain by treating with mycophenolic acid , an inhibitor of the inosine monophosphate dehydrogenase.”

“ MPA exerts its immunosuppression by inhibiting inosine 5'-monophosphate dehydrogenase (IMPDH), depleting activated lymphocytes of guanine nucleotides and retarding their proliferation.”

“Mycophenolic acid MPA ) is a selective inhibitor of inosine 5′-monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme of de novo synthesis of guanine nucleotides.”

“ Mycophenolic acid , the active metabolite of MMF, selectively inhibits inosine 5’-monophosphate dehydrogenase, a key enzyme of the purine de novo synthesis pathway of guanosine nucleotides [1].”

“ MPA , a fermentation product of Penicillium brevicompactum and related fungi, is an inhibitor of inosine monophosphate dehydrogenase, a key enzyme in the de novo pathway of purine synthesis.”

“BACKGROUND The mechanism of action of mycophenolic acid (MPA) has been described as a blockade of inosine 5'-monophosphate dehydrogenase (IMPDH) and is thought to selectively influence T- and B-lymphocytes due to their strong dependency on guanine nucleotides synthesized via the de novo purine synthesis pathway.”

“ MPA is a well-known inhibitor of inosine monophosphate dehydrogenase and anti-HIV activity has been reported in vitro and in vivo.”