Possible Interaction: Inosine and Mycophenolate Mofetil

“ MMF inhibits the inosine monophosphate dehydrogenase that has been shown to have in vitro antiviral properties against flaviviruses, suggesting the possibility that it might also inhibit the hepatitis C virus (HCV).”

“ Mycophenolate-mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase, which is necessary for de novo purine biosynthesis in lymphocytes.”

“ MMF , a non-competitive inhibitor of inosine monophosphate dehydrogenase, blocks de novo purine synthesis in T and B lymphocytes, resulting in the selective inhibition of proliferation of these cells in response to antigenic stimuli.”

“ Mycophenolate mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase, which affects de novo purine synthesis and T- and B-cell proliferation.”

“ MMF selectively inhibits inosine 5′-monophosphate dehydrogenase type II, responsible for de novo synthesis of the purine nucleotide guanine.”

“ MMF is an irreversible inhibitor of inosine monophosphate dehydrogenase in lymphocytes and affects lymphocytic proliferation and activation.”

“ Mycophenolate mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase and thus de novo purine synthesis.”

“Via its metabolite mycophenolic acid (MPA), MMF interferes with the metabolic pathway of de novo purine synthesis through inhibition of inosine monophosphate dehydrogenase, suppressing both B and T lymphocyte proliferation3.”

“ MMF is a selective inhibitor of inosine monophosphate dehydrogenase, thus blocking purine synthesis via the de novo pathway preferentially used by T and B lymphocytes.”

“Background MMF is a potent immunosuppressant that is a selective inhibitor of inosine 5′-monophosphate dehydrogenase type II, the enzyme responsible for the de novo synthesis of the purine nucleotide guanine within activated T and B lymphocytes and macrophages.”