Possible Interaction: Inosine and Mizoribine

“In the LS180 cells, ribavirin and inosine reduced the uptake of 400 microM mizoribine with the increasing concentrations (from 5 to 50 mM) of the inhibitors.”

“Mycophenolic acid and mizoribine inhibit inosine monophosphate dehydrogenase, thereby depleting guanosine nucleotides.”

“ Mizoribine depletes guanosine nucleotides by inhibiting inosine monophosphate dehydrogenase and may increase the ratio of ganciclovir to guanosine in treated cells, resulting in a strong synergistic augmentation of the anti-CMV activity of ganciclovir.”

“Coadministration of adenosine, inosine and mizoribine , but not thymidine and gemcitabine, significantly suppressed the intestinal absorption of ribavirin, indicating that ribavirin absorption is mediated by CNT2 in rats.”

“It is conceivable that inosine and inosinic acid might affect the intestinal absorption of mizoribine , an imidazole nucleoside that inhibits the de novo production pathway of guanine ribonucleotide.”

“Urinary recovery rates of mizoribine were significantly decreased by pretreatment with inosine or inosinic acid.”

“Mizoribine MZ ) inhibits the proliferation of lymphocytes selectively via inhibition of inosine monophosphate dehydrogenase, like mycophenolate mofetil (MMF).”