Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Inosine and Methotrexate

supplement:

Inosine

Research Papers that Mention the Interaction

The protecting agents employed, thymidine and inosine , circumvent the antipurine and antipyrimidine effects of MTX , but neither agent inhibits the transport or the polyglutamylation of MTX.
Cancer treatment reports  •  1985  |  View Paper
It is concluded that co-administration of inosine and/or thymidine allows the use of methotrexate doses otherwise not tolerated, though with loss of anti-tumor effect.
European journal of cancer & clinical oncology  •  1984  |  View Paper
The infusion of inosine alone or in combination with thymidine blocked both the toxicity and antitumor activity of methotrexate.
Cancer research  •  1978  |  View Paper