supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Inosine
drug:
Methotrexate
Research Papers that Mention the Interaction
“The protecting agents employed, thymidine and inosine , circumvent the antipurine and antipyrimidine effects of MTX , but neither agent inhibits the transport or the polyglutamylation of MTX.”
Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.“However, the diminishing effect on survival with thymidine and inosine doses above 0.5 mg/hr indicated loss of the antitumor effect of methotrexate.”
“It is concluded that co-administration of inosine and/or thymidine allows the use of methotrexate doses otherwise not tolerated, though with loss of anti-tumor effect.”
“The infusion of inosine alone or in combination with thymidine blocked both the toxicity and antitumor activity of methotrexate.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback