Discover Supplement-Drug Interactions
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8 months ago
Possible Interaction: Inosine and Methotrexate
Research Papers that Mention the Interaction
“The protecting agents employed, thymidine and
, circumvent the antipurine and antipyrimidine effects of
, but neither agent inhibits the transport or the polyglutamylation of MTX.”
Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.
Cancer treatment reports • 1985 |
“However, the diminishing effect on survival with thymidine and
above 0.5 mg/hr indicated loss of the antitumor effect of
“It is concluded that co-administration of
and/or thymidine allows the use of
doses otherwise not tolerated, though with loss of anti-tumor effect.”
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
European journal of cancer & clinical oncology • 1984 |
“The infusion of
alone or in combination with thymidine blocked both the toxicity and antitumor activity of
Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.
Cancer research • 1978 |
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