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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Inosine and Methotrexate



Research Papers that Mention the Interaction

The protecting agents employed, thymidine and inosine , circumvent the antipurine and antipyrimidine effects of MTX , but neither agent inhibits the transport or the polyglutamylation of MTX.
Cancer treatment reports  •  1985  |  View Paper
However, the diminishing effect on survival with thymidine and inosine doses above 0.5 mg/hr indicated loss of the antitumor effect of methotrexate.
It is concluded that co-administration of inosine and/or thymidine allows the use of methotrexate doses otherwise not tolerated, though with loss of anti-tumor effect.
European journal of cancer & clinical oncology  •  1984  |  View Paper
The infusion of inosine alone or in combination with thymidine blocked both the toxicity and antitumor activity of methotrexate.
Cancer research  •  1978  |  View Paper