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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Vitamin E
Research Papers that Mention the Interaction
“In the presence of indomethacin , a cyclooxygenase inhibitor, AT inhibited IL-1 beta activity.”
Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase.“Since MSF shares a number of pharmacological properties with vitamin E , which also increases indomethacin anti-inflammatory activity while reducing indomethacin toxicity, it is suggested that MSF has this for its vitamin E-like activity perhaps as a result of altering the arachidonic acid cascade.”
Influence of 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on carrageenan-induced inflammation and anti-inflammatory and toxic effects of indomethacin in rats“In vivo experiments on animals have demonstrated that vi amin E de creases the toxicity of several compounds, including nitrogen dioxide (Elsayed and Mustafa 1982), hydrazine (Antosiewicz et al. 1994a), and methyl ethyl ketone peroxide (MEKP) (And o an d Tappel 1985).”
“Addition of the platelet inhibitor indomethacin to vitamin E simultaneously suppressed 8,12-iso-iPF2&agr;-VI and TxB2, significantly reduced soluble intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, and remarkably, further reduced atherosclerosis (80%).”
“Antioxidants tocopherol acetate , essentiale, legalon, flacumin) limit manifestations of indomethacin , hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree.”
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