Possible Interaction: Indomethacin and Vitamin C

“I believe this movement started when a study on Gardner’s syndrome (familial adenomatous polyposis) found that sulindac and indomethacin plus high-dose vitamin C caused regression of intestinal polyps, resulting in fewer colorectal cancers, as well as a decrease in desmoid tumors [10].”

“The precise mechanism(s) responsible for this effect are unknown, but in both species an acute indomethacin treatment reverses the action of the ascorbic acid.”

“This stimulatory effect of ascorbic acid was concentration-dependent and was inhibited by indomethacin.”

“Administration of 50 mg of indomethacin , orally, reversed the effect of ascorbic acid.”

“This ameliorating action of ascorbic acid was blocked by ingestion of indomethacin.”

“When large doses of ascorbic acid were given with indomethacin , slow resolution of the tumor began and has continued for 14 months.”

“ Ascorbic acid , a promising antioxidant, could significantly reduce celecoxib and indomethacin induced lipid peroxidation.”

“ Indomethacin , but not L-NAME, partially inhibited the relaxing effect of ascorbic acid.”

“The present results thus suggested that IM may exert inhibitory effects on promotion of bladder carcinogenesis by certain tumor promoter types, and AsA may enhance BHA forestomach carcinogenesis.”

“Thus, a single oral dose of ascorbic acid at levels 5-25 times the recommended intake, can elevate body temperature significantly in healthy guinea pigs, a phenomenon which is inhibited by indomethacin administration.”