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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Indomethacin and four congeners were shown by equilibrium dialysis to interfere with the binding of L-tryptophan at the primary indole binding site on defatted human serum albumin.”
Functional modification of indole binding site with indomethacin congeners.“Pretreatment with indomethacin , to block the biosynthesis of prostaglandins, significantly augmented the lesions produced by stress and completely abolished the protective effects of melatonin or L-tryptophan.”
Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischaemia-induced lesions is mediated by scavenge of oxygen radicals.“ Tryptophan and histidine given in low doses promoted a decrease of the indomethacin elevated levels of serotonin and histamine in the gastric mucosa.”
“Of the drugs examined, sodium salicylate, sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated the synthesis of 5-HT in the brain.”
“ Indomethacin (5 mM), phenylbutazone (5 mM), and salicylate (15 mM) prevent the active transport of the amino acid, L-tryptophan , across the small intestine of the rat.”
“Abstract Arginine, phenylalanine, and tryptophan have been previously shown to improve the solid‐state stability of amorphous indomethacin.”
Dissolution behavior of co‐amorphous amino acid‐indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin
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