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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Trypsin
Research Papers that Mention the Interaction
“The contractile responses produced by thrombin, trypsin , SFLLRN‐NH2 and SLIGRL‐NH2 were markedly reduced in the presence of the cyclo‐oxygenase inhibitor, indomethacin , whilst the small contractile response produced by NRLLFS‐NH2 and LRGILS‐NH2 were insensitive to indomethacin.”
Evidence that PAR‐1 and PAR‐2 mediate prostanoid‐dependent contraction in isolated guinea‐pig gallbladder“Activation of Cl(-) secretion by trypsin was inhibited by indomethacin and was further increased by cAMP in normal tissues but was not present in CF colon, indicating the requirement of luminal CF transmembrane conductance regulator.”
“Removal of the endothelium but not treatment with L-NAME (300 &mgr;mol/L), indomethacin (5 &mgr;mol/L), or oxyhemoglobin (10 &mgr;mol/L) inhibited the response to SLIGRL and trypsin.”
Protease-Activated Receptor-2 Activation Causes EDHF-Like Coronary Vasodilation: Selective Preservation in Ischemia/Reperfusion Injury: Involvement of Lipoxygenase Products, VR1 Receptors, and C-Fibers“Permeability changes, evaluated by fluorescence microscopy after injection of FITC-dextran (MW 150,000), induced by trypsin (2.5 microM) and trypsinated serum (2.5 microM) were significantly suppressed by pretreatment with NDGA (20 mg/kg) and indomethacin (20 mg/kg).”
“Titration of the apoenzyme with indomethacin (0-3 mol/mol of synthase dimer) resulted in proportional increases in the inhibition of the cyclooxygenase and in the resistance to attack by trypsin.”
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