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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Indomethacin
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Synergistic inhibition by combined treatment of indomethacin and RA was seen in RA responsive lines of SCC15 and SCC25, whereas other RA-resistant clones showed no synergism of this combined treatment.”
In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis.“Furthermore, indomethacin potentiated apoptosis in cells treated with a differentiating agent, all-trans retinoic acid , which induces resistance to TNF-alpha.”
“In contrast, suppression of IFN‐γ‐induced ICAM‐1 expression by RA was only partly reversible by indomethacin , suggesting that inhibition of IFN‐γ stimulation was not completely due to cyclooxygenase induction.”
“ Indomethacin shifted the G-CSF dose-response curve of cells treated with 10 nM RA to lower G-CSF concentrations.”
“The results demonstrate that indomethacin increases TNBS-induced fibrosis in mice, while RA reduces it, and that SPARC may link these opposing effects.”
Indomethacin and Retinoic Acid Modify Mouse Intestinal Inflammation and Fibrosis: A Role for SPARC“The combination of the cyclooxygenase inhibitor, indomethacin , at 10(-4) M with 10(-6) M RA lowered MFB fibroblast cell numbers when compared to fibroblasts cultured singly with either RA or indomethacin.”
“ Indomethacin completely inhibited induction of I-activity by retinoic acid.”
“ Indomethacin inhibited the induction of lysozyme activity by retinoic acid.”
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