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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Indomethacin
supplement:
Taurine
Research Papers that Mention the Interaction
“This neutrophil adhesion induced by indomethacin to HUVEC was prevented by taurine in a dose-dependent manner.”
Protective effect of taurine on indomethacin-induced gastric mucosal injury.“When indomethacin , a non-selective COX inhibitor was administered before the last dose of taurine zinc, the gastroprotective effect of taurine zinc was weakened.”
Gastroprotective effect of taurine zinc solid dispersions against absolute ethanol-induced gastric lesions is mediated by enhancement of antioxidant activity and endogenous PGE2 production and attenuation of NO production.“A significant increase in blood pressure was observed in rats cotreated with the inhibitors Hoe 140 (a kinin receptor blocker), L-NAME (a NO synthase inhibitor), or indomethacin (a PG synthesis inhibitor) with taurine for 1 week as compared with taurine-treated fructose-fed rats.”
“Furthermore, the effect of indomethacin on TxA2 and 6-keto-PGF1 alpha concentrations could be reversed by taurine.”
“ Indomethacin (10 micrograms, a cyclo-oxygenase inhibitor) pretreatment significantly decreased baseline prostaglandin E2 release in control animals (61 +/- 6%) and suppressed kainic acid-evoked aspartate, taurine and prostaglandin E2 release, but had no effect on the concentration of glutamate after kainic acid injection.”
“In addition, hyposmotically induced taurine efflux was slightly but significantly inhibited by the cyclooxygenase inhibitor indomethacin (10 microM).”
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