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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Senna
Research Papers that Mention the Interaction
“Significant changes induced by sennoside A were attenuated by indomethacin treatment.”
Regionally differential effects of sennoside A on spontaneous contractions of colon in mice.“The colonic motor changes induced by intracolonic sennosides at the minimal effective dose, but not those induced by intracolonic PGE2, were blocked by intra-arterial indomethacin (10 micrograms/h) or piroxicam (5 micrograms/h).”
“ Indometacin , loperamide, and calcium-channel antagonists (verapamil, nifedipine) partially antagonized the effect of intracecal sennosides on LIT and delayed, but did not suppress, appearance of soft feces.”
“Inhibition of PG biosynthesis by pretreatment of the rats with indomethacin significantly inhibited the effects of senna pod extract both on net fluid transport and on PGE2 release.”
“The inhibitory effect of indomethacin on net fluid transport induced by senna pod extract was dose-dependent.”
“ Indomethacin partly inhibited the acceleration of large intestine transit induced by sennosides.”
“While indomethacin significantly reduced the PGE content of all tissue in all treatment groups it did not completely prevent the increase in PGE content induced by phenolphthalein, senna and ricinoleic acid.”
“ Indomethacin reduced the effect of dioctyl sodium sulphosuccinate and of sennoside A + B on PGE release but not their effect on the net water flux.”
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