Possible Interaction: Indomethacin and Secretin

“Endogenous prostaglandins play an important intermediary role, because indomethacin pretreatment prevents the physiological actions of secretin.”

“ Indomethacin (2 mg kg−1) reduced gastric relaxation induced by secretin (5.6 pmol kg−1 h−1) by 87 ± 5%.”

“Intravenous administration of prostaglandin synthesis inhibitor, indomethacin (2 mg/kg + 1 mg/kg/h), completely abolished both the inhibitory action of secretin and plaunotol on gastric acid secretion, and the increase in gastric mucosa prostaglandin E2 induced by secretin and plaunotol.”

“ Secretin significantly increased the gastric mucosal content of prostaglandin E2, and the increase was completely blocked by indomethacin.”

“Dose-dependent increases in pancreatic exocrine secretion of water and bicarbonate were observed with IV infusion of neurotensin or secretin ; however, inhibition of prostaglandin synthesis by indomethacin abolished this response.”

“The authors have previously shown that neurotensin and secretin inhibit gastric acid secretion in the dog and that these actions are inhibited by the prostaglandin synthesis inhibitor indomethacin.”

“The inhibition produced by either oleic acid or secretin was completely blocked by indomethacin.”

“3) Antisomatostatin serum and indomethacin blocked the inhibitory effect on antral motility induced by secretin.”

“ Indomethacin could block stimulatory affects of secretin on PGE, 6-Keto-PGF1 alpha release and somatostatin on PGE release.”

“ Indomethacin could reverse the inhibitory effects of acid secretion by secretin and somatostatin. (”

“Both indomethacin and meclofenamate abolished the inhibitory effects of secretin on gastric acid secretion.”

“The effect of caerulein but not of secretin to stimulate the flow rate of pancreatic exocrine secretion was reduced by indomethacin and meclofenamate.”