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Possible Interaction: Indomethacin and Secretin



Research Papers that Mention the Interaction

Endogenous prostaglandins play an important intermediary role, because indomethacin pretreatment prevents the physiological actions of secretin.
Journal of clinical gastroenterology  •  1995  |  View Paper
Indomethacin (2 mg kg−1) reduced gastric relaxation induced by secretin (5.6 pmol kg−1 h−1) by 87 ± 5%.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society  •  2009  |  View Paper
Intravenous administration of prostaglandin synthesis inhibitor, indomethacin (2 mg/kg + 1 mg/kg/h), completely abolished both the inhibitory action of secretin and plaunotol on gastric acid secretion, and the increase in gastric mucosa prostaglandin E2 induced by secretin and plaunotol.
The American journal of gastroenterology  •  1993  |  View Paper
Secretin significantly increased the gastric mucosal content of prostaglandin E2, and the increase was completely blocked by indomethacin.
Digestion  •  1993  |  View Paper
Dose-dependent increases in pancreatic exocrine secretion of water and bicarbonate were observed with IV infusion of neurotensin or secretin ; however, inhibition of prostaglandin synthesis by indomethacin abolished this response.
The authors have previously shown that neurotensin and secretin inhibit gastric acid secretion in the dog and that these actions are inhibited by the prostaglandin synthesis inhibitor indomethacin.
Gastroenterology  •  1992  |  View Paper
The inhibition produced by either oleic acid or secretin was completely blocked by indomethacin.
The American journal of physiology  •  1991  |  View Paper
3) Antisomatostatin serum and indomethacin blocked the inhibitory effect on antral motility induced by secretin.
Sheng li xue bao : [Acta physiologica Sinica]  •  1990  |  View Paper
Indomethacin could block stimulatory affects of secretin on PGE, 6-Keto-PGF1 alpha release and somatostatin on PGE release.
Indomethacin could reverse the inhibitory effects of acid secretion by secretin and somatostatin. (
Sheng li xue bao : [Acta physiologica Sinica]  •  1989  |  View Paper
Both indomethacin and meclofenamate abolished the inhibitory effects of secretin on gastric acid secretion.
Gastroenterology  •  1988  |  View Paper
The effect of caerulein but not of secretin to stimulate the flow rate of pancreatic exocrine secretion was reduced by indomethacin and meclofenamate.
The American journal of physiology  •  1983  |  View Paper