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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Quercetin
Research Papers that Mention the Interaction
“ Quercetin prevented the decrease in nuclear translocation of Nrf2, a key regulator … response, and the increase in reactive oxygen species levels induced by INDO by inhibiting the enhancement of NADPH oxidase and xanthine oxidase activities as well … in superoxide dismutase and glutathione peroxidase activities in gastric and ileal tissues.”
Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2.“However, binding of quercetin is much more favorable in the presence of indomethacin , with its position and interactions with HSA significantly changed.”
“The protective effect of quercetin was associated with its capacity to inhibit the redistribution of ZO-1 protein induced in the tight junction by indomethacin or rotenone, a mitochondrial complex-I inhibitor, and to prevent the decrease of ZO-1 and occludin expression induced by indomethacin.”
“ QUE was the most efficient polyphenol in preventing Ca(2+) mobilization induced by INDO and all of its consequences including cytotoxicity and apoptosis.”
“Steroid hormones (17beta-estradiol, progesterone and cortisol), flavonoids (genistein and quercetin ) and non-steroidal anti-inflammatory drugs (NSAIDs) ( indomethacin and diclofenac) inhibit [(14)C]AA uptake in a dose-dependent and non-competitive manner.”
“L-NAME, indomethacin , and ODQ treatment also decreased the potency of quercetin.”
Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study“The cyclooxygenase blocker indomethacin (10−5moles/lit) induced no relaxation but contraction when physiological concentrations of quercetin were present in the tissue bath (p<0.02 with Anova), this contraction being more prominent in smaller vessels and in the higher pressure range (p<0.05, Pearson correlation).”
“Pretreatment with indomethacin (10 micromol/L) attenuated the vasodilatation of quercetin , but did not affect the vascular effect of rutin.”
“Furthermore, both nitro-L-arginine-methyl ester (L-NAME, 100 microM) and indomethacin (10 microM) markedly attenuated the vasorelaxant responses following quercetin application.”
“Furthermore, indomethacin only slightly reversed protective effect of quercetin.”
“On the other hand, application of quercetin prevented this significant decrease even in animals pretreated with indomethacin.”
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