Possible Interaction: Indomethacin and Potassium

“ Indomethacin treatment effectively controlled the increased prostaglandin excretion but corrected only partially the potassium and the calcium losses.”

“This case suggests that life-threatening hyperkalemia can occur when indomethacin and potassium supplementation are prescribed simultaneously in Bartter's syndrome.”

“ Indomethacin promptly reduced urinary excretion of sodium, potassium , chloride and PGE, and markedly suppressed the renin-aldosterone system.”

“The results indicate that indomethacin as long-term treatment may be ineffective in maintaining a normal potassium balance in BS.”

“These results indicate that acute administration of indomethacin impairs the response to a potassium load , not as a result of inhibition of aldosterone secretion or extrarenal potassium distribution but by means of inhibition of renal potassium excretion.”

“In addition, indomethacin fully inhibited the stimulatory effect of 19− and 20-HETE on relaxation induced by potassium.”

“Pretreatment with indomethacin significantly improved CIn and CPAH, and potassium repletion abolished this effect entirely.”

“ Indomethacin did not alter the response to norepinephrine but augmented that to potassium.”

“ Indomethacin and aspirin decreased the amounts of prostaglandins formed, allowed the accumulation of free arachidonic acid, and diminished the potassium‐stimulated release of [3H]dopamine.”

“The indomethacin , injected IV, in an other group of animals, decreased RPF, GFR, Sodium and Potassium excretion rate and PRA, and it increased the EPAH and FF.”