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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Phosphatidic Acid
Research Papers that Mention the Interaction
“However, a small increase in the thrombin concentration (to 0.1 unit/ml) induces platelet aggregation, release of serotonin, and a sharp increase in PA accumulation which are effectively inhibited by indomethacin.”
“Low concentrations of thrombin (0.05 units/ml) induce only platelet shape change and a small stimulation of PA , changes which are only minimally inhibited by indomethacin.”
A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen.“ Indomethacin inhibited the biosynthesis of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and phosphatidic acid.”
Endogenous prostaglandins regulate rat renal phospholipid 'de novo' synthesis.
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