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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Oxytocin
Research Papers that Mention the Interaction
“Atosiban, 5HD, L-NAME and indomethacin abolished the postconditioning effect of OT.”
Stimulation of Oxytocin Receptor during Early Reperfusion Period Protects the Heart against Ischemia/Reperfusion Injury: the Role of Mitochondrial ATP-Sensitive Potassium Channel, Nitric Oxide, and Prostaglandins.“ Oxytocin failed (P<0.001) to elicit PGF2α release in explants cultured with either Atosiban or indomethacin.”
“However, the OT positive effect was not blocked by mifepristone (P4 antagonist), but was inhibited by indomethacin (a non-selective PTGS2 inhibitor).”
“Pretreatment with systemic injection of the prostaglandin synthesis inhibitor indomethacin dose‐dependently reduced the oxytocin response and prevented the vasopressin response to histamine or LPS.”
“These changes caused by oxytocin were prevented by indomethacin , a prostaglandin synthetase inhibitor, although indomethacin given alone did not affect luteal function.”
“Mepacrine, NDHG and indomethacin also inhibited tonic contractions by OT in calcium-free EDTA treated medium.”
“Mepacrine, NDHGA and indomethacin , but not imidazol, inhibited in a dose-dependent way contractions induced by OT in the uterus.”
“In contrast, OXY release in response to hemorrhage of either 22 or 44% of the blood volume of the rat was enhanced by indomethacin.”
“ Indomethacin increased the hemorrhage-induced OXY levels about 2-fold over a 2-hour posthemorrhage period.”
“The paradoxical effects of indomethacin on OXY release suggest that the prostaglandins may have different effects on OXY release depending upon the evoking stimulus.”
“Daily subcutaneous administration of the prostaglandin synthetase inhibitor indomethacin (10 mg kg-1) between days 11 and 16, delayed luteolysis and suppressed both the decline in oxytocin concentrations and the pulsatile appearance of both oxytocin and PGFM in the peripheral circulation.”
“2 Indomethacin , an inhibitor of cyclo‐oxygenase, did not reduce the response to angiotensin II but did abolish the contractile response to low doses of oxytocin.”
“4) In isolated uterine horns, the contractile response to OT was only slightly attenuated in the presence of indomethacin sufficient to inhibit completely the OT-stimulated PG synthesis.”
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