Possible Interaction: Indomethacin and Ovalbumin

“Among the NSAIDs, diclofenac and indomethacin increased sensitization to OVA , similar to high-dose aspirin, but meloxicam exerted no effects on Ab levels.”

“The maximal response (but not EC50 for ovalbumin ) was significantly (P less than 0.01) enhanced by indomethacin (20%), only slightly (10%) inhibited by the histamine H1-antagonist pyrilamine and unaffected by the platelet-activating factor (PAF) antagonist CV-3988.”

“4 The release of cyclo‐oxygenase products following ovalbumen challenge was not inhibited by CGS 8515, but was markedly inhibited by indomethacin (2.8 μm) pretreatment.”

“ Indomethacin at higher dose (10 mg/kg) and BW755c (10 mg/kg) decreased the potentiation of the respiratory insufflation pressure to ovalbumin.”

“ Indomethacin potentiated both histamine release and contraction induced by ovalbumin.”

“ Indomethacin , 5 X 10(-6) M, did not alter … contraction produced by a submaximum concentration of ovalbumin and impeded return to basal tension, 5,8,11,14-Eicosatetraynoic acid, 10(-5) M, in … of this contraction and reduced by 50% the total SRS-A released without altering histamine release.”

“Pretreatment with high doses of indomethacin resulted in only 60% inhibition of the OA induced contraction, suggesting the remaining contraction was due to something other than cyclooxygenase products.”

“ Indomethacin , 5 x 10(-6) M, produced a small increase in the maximum response to ovalbumin and a small (2-fold) rightward shift of the histamine dose-response curve.”

“In the presence of 10(-6)M atropine, pyrilamine, and indomethacin , concentrations of ovalbumin from 10(-9) to 10(-8) g per ml produced marked contraction of the bronchi.”