Possible Interaction: Indomethacin and Oleic Acid

“However in indomethacin pretreated rats, injection of oleic acid produced instantaneous decrease in RF and all the animals died within 10 min (mean survival time = 6.6±1.07 min).”

“The FFR in the indomethacin group was significantly greater than in the control and Diethylcarbamazine (DEC) groups 12 min after OA (7.6 +/- 2.3 mg.min-1 vs. 2.3 +/- 0.8 mg.min-1 and 0.96 +/- 0.8 mg.min-1 respectively) (P < 0.01).”

“ Oleic acid caused a significant increase at 3 h in % increase in A-aPo2 from baseline (105 +/- 12%) attenuated by PEEP (59 +/- 17%) and indomethacin (57 +/- 7%), with the combination of PEEP + indomethacin preventing a significant increase (26 +/- 9%).”

“The inhibition produced by either oleic acid or secretin was completely blocked by indomethacin.”

“However, the enhancing effect of percutaneous absorption of ID diminished when the OA content in the vehicle exceeded 50%.”

“In particular, the maximal enhancement of percutaneous absorption of ID was achieved at 5% OA.”

“It was observed that when OA was added to the vehicles in the range of 5 to 30%, the percutaneous absorption of ID from the vehicles was increased.”

“Inhibition of PGE biosynthesis by pretreatment of the rats with indomethacin significantly reduced (but did not abolish) the effect of ricinoleic, oleic and deoxycholic acids on net water flux and PGE release.”

“Arachidonic, but not oleic , acids increased lipid peroxidation in the renal medulla, but this augmentation is inhibited by indomethacin.”