Possible Interaction: Indomethacin and Melatonin

“CONCLUSION The results of the present study showed that, administration of me atonin 3 mg tablets plus ind omethacin su ppository 100 mg 1 h before ERCP could decrease the PEP rate and amylase and lipase levels compared to administration of indomethacin suppository 100 mg alone.”

“Previous studies showed that nonsteroidal anti-inflammatory drugs such as ibuprofen and indomethacin suppress melatonin secretion and alter the circadian rhythm [6].”

“The second part of this study showed that the administration of indomethacin (100 mg/day) to normal healthy subjects led to a 14.7 pg/ml decrease in plasma melatonin levels.”

“This may indicate that melatonin and indomethacin act synergistically.”

“ Indomethacin administered alone increased the incidence of tumors by 21.5% (also in combination with melatonin ) and reduced the tumor latency by 17 days compared to controls.”

“ Melatonin reversed the effect of indomethacin during protection of gastric ulcers in diabetic rats.”

“Histologic studies of gastric mucosa further document that melatonin almost completely protects against gastric damage induced by indomethacin.”

“ Melatonin inhibits the important steps of indomethacin‐induced activation of mitochondrial pathway of apoptosis such as upregulation of the expression of Bax and Bak, and the downregulation of Bcl‐2 and BclxL. Melatonin also prevents indomethacin‐induced mitochondrial translocation of Bax and prevents the collapse of mitochondrial membrane potential.”

“Moreover, melatonin reduces indomethacin‐mediated activation of caspase‐9 and caspase‐3 by blocking the release of cytochrome c and finally rescues gastric mucosal cells from indomethacin‐induced apoptosis as measured by the TUNEL assay.”

“Using an array of experimental approaches, we have shown that melatonin prevents the development of mitochondrial oxidative stress and activation of mitochondrial pathway of apoptosis induced by indomethacin (a NSAID) in the gastric mucosa.”

“ Indomethacin and rofecoxib, which diminished PGE2 biosynthesis by c. 90 and 75% or capsaicin denervation, attenuated significantly melatonin‐ and l‐tryptophan‐induced protection and the rise in the GBF.”

“ Melatonin dose‐dependently lowered piroxicam and indomethacin‐induced gastric damage with more than 90% inhibition at a dose of 60 mg/kg BW.”

“Pretreatment with melatonin prevented the increase by subsequently administered indomethacin in the renal activity of lipid peroxidation and acid phosphatase.”

“The results indicated inability of oral administration of melatonin to prevent some of the oxidative damaging effects of indomethacin in the rat testis.”